Year: 2024
Type: article
Abstract: Abuse of the highly toxic compound fentanyl and its analogues is increasing, raising serious public health concerns due to their potency and availability. Therefore, there is a need for decontamination methodologies to safely remove fentanyl to avoid harmful exposure. In this study, the efficacy of commercial and in-house synthesized decontamination agents (Dahlgren Decon, RSDL (Reactive Skin Decontamination Lotion), FAST-ACT (First applied sorbent treatment against chemical threats), GDS2000, alldecont MED, bleach, Domestos Spray Bleach, Effekt Klor, MgO, TiO 2 -nanodiamond, and CeO 2 ) were evaluated for the degradation of fentanyl and carfentanil under controlled laboratory conditions and on wooden floor surfaces. Liquid chromatography/mass spectrometry analysis showed that oxidative decontamination agents were the most effective, with N-oxides identified as major degradation products. The physiological effects of these N-oxides were also investigated regarding their ability to activate the µ-opioid receptor and their metabolism in human liver microsomes. The results provide empirical evidence that complements prior research findings on the degradation of fentanyl and carfentanil using a variety of decontamination agents.
Source: Scientific Reports
Authors: Pernilla Lindén, Lina Mörén, Johanna Qvarnström, Nina Forsgren, Cecilia Springer Engdahl, Magnus Engqvist, Jiri Henych, Tobias Tengel, Lars Österlund, Lina Thors, Andreas Larsson, Susanne Johansson
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funder: Svenska Forskningsrådet Formas
OpenAlex ID: W4403763485