Year: 2024
Type: article
Abstract: Bone sarcoma, a group of aggressive cancers arising from bone or soft tissues, remains challenging to treat effectively. This study investigates the potential of Marumoside A, a phytochemical, as a therapeutic agent against bone sarcoma using computational methods. Molecular docking was performed to explore the interactions between Marumoside A and key protein targets involved in bone sarcoma progression. Binding affinities and interaction profiles were analyzed to identify its mechanism of action. Drug-likeness and ADMET properties were assessed using SwissADME and StopTox tools, confirming compliance with pharmacokinetic and safety requirements. Marsumoside A exhibited strong binding affinities, favorable pharmacokinetic properties, and a low toxicity profile, highlighting its promise as a candidate for further preclinical evaluation. These findings underscore the therapeutic potential of Marumoside A in bone sarcoma treatment and warrant experimental validation.
Authors: SP Yamoona, M Indirani, D Pooja
Institution: Alagappa University
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4403763990