Computed Tomography and Magnetic Resonance Imaging in Liver Iron Overload: From Precise Quantification to Prognosis Assessment
Year: 2024
Type: article
Abstract: Liver iron overload is associated with conditions such as hereditary hemochromatosis, thalassemia major, and chronic liver diseases. The liver-related outcomes, patient outcomes, and treatment recommendations of these patients differ depending on the cause and extent of iron overload. Accurate quantification of the liver iron concentration (LIC) is critical for effective patient management. This review focuses on the application of computed tomography (CT) and magnetic resonance imaging (MRI) for the precise quantification and prognostic assessment of liver iron overload. In recent years, the use of dual-energy CT and the emergence of MRI-based sequences (such as UTE, QSM, Dixon, and CSE technologies) have significantly increased the potential for noninvasive liver iron quantification. However, the establishment of internationally standardized imaging parameters, postprocessing procedures, and reporting protocols is urgently needed for better management of patients with liver iron overload.
Source: Biomedicines
Authors: Xinrui Zhou, Xinyuan Jia, Yidi Chen, Bin Song
Institutions: Sichuan University, West China Hospital of Sichuan University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,955
OpenAlex ID: W4403764648