Work

Synthesis of Perfluoroalkylated Pyrazoles from α-Perfluoroalkenylated Aldehydes

Year: 2024

Type: article

Abstract: Within this study, we report a simple two-step process for the synthesis of perfluoroalkylated pyrazoles from aliphatic aldehydes. In the photocatalytic first step, the aldehydes are transformed into the corresponding perfluoroalkylated enals, which then undergo nucleophilic attack by hydrazine and subsequent ring closure, providing the fluorinated 3,4-substituted pyrazole products in a 64-84% yield. Using triphenylphosphine and imidazolidinone as organocatalysts, the method is operationally simple and omits heavy metal-containing waste.

Source: Molecules

DOI: 10.3390/molecules29215034

Authors: Lennart Bunnemann, Christian Wulkesch, Victoria Carina Voigt, Constantin Czekelius

Institution: Heinrich Heine University Düsseldorf

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,069

Funder: Deutsche Forschungsgemeinschaft