Work

Optimizing chemically stable chloramphenicol in-situ gel formulations using poloxamer 407 and HPMC through full-factorial design

Year: 2024

Type: article

Abstract: The primary goal was to enhance the stability and bioavailability of chloramphenicol for ophthalmic use without compromising patient comfort, such as causing blurry vision. This study employed a 2-level full factorial design to optimize the formulation, exploring different concentrations of poloxamer 407 and HPMC to achieve this objective.

Source: Scientific Reports

DOI: 10.1038/s41598-024-74945-w

Authors: Insan Sunan Kurniawansyah, Taofik Rusdiana, Insi Farisa Desy Arya, Handrian Ramoko, Habibah A. Wahab

Institutions: Padjadjaran University, Universiti Sains Malaysia

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590