Work

Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

Year: 2024

Type: article

Abstract: values below the micromolar threshold. The cell damage induced by 1 proved to be strictly connected with the overproduction of reactive oxygen species (ROS) responsible for mitochondrial dysfunction leading to the activation of caspases and then to apoptosis, and for DNA photocleavage leading to cell cycle arrest.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00600c

Authors: Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti

Institutions: National Research Council, University of Naples Federico II, Institute for Experimental Endocrinology and Oncology, Scuola Superiore Meridionale

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funder: European Regional Development Fund

Award: G1888088267

OpenAlex ID: W4403770067

FWCI: 0.762

Cites: 68

Cited by: 3

Related to: 10