Work

Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

Year: 2024

Type: article

Abstract: INTRODUCTION: Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood. METHODS: In this single-center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients. RESULTS: EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively. CONCLUSION: Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long-term survival.

Source: eJHaem

DOI: 10.1002/jha2.1037