Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective
Year: 2024
Type: article
Abstract: Drug repurposing, also known as drug repositioning, involves identifying new applications for drugs whose effects in a disease are already established. Doxycycline, a broad-spectrum antibiotic belonging to the tetracycline class, has demonstrated potential activity against neurodegenerative diseases like Alzheimer's and Parkinson's. However, despite its promise, the repurposed use of doxycycline encounters challenges in reaching the brain in adequate concentrations to exert its effects. To address this issue, nanostructured systems offer an innovative approach that can enhance brain targeting and the desired therapeutic outcomes. This review discusses the advances in doxycycline repurposing for Alzheimer's disease, presenting physicochemical and biological aspects that permeate doxycycline's repositioning and its application in nano-based delivery systems. • Doxycycline has shown potential activity against beta amyloid-induced memory impairment; • Doxycycline's physicochemical properties allows its encapsulation by nanoparticles; • Doxycycline applied into nano-based delivery systems may improve brain targeting.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,540
OpenAlex ID: W4403776521