Important ultrasonography and CT findings and prognostic factors of incidentally detected gallbladder cancer
Year: 2024
Type: article
Study design: Observational Study
Abstract: AIMS: To evaluate important imaging findings and prognostic factors of incidentally detected gallbladder cancer (IDGC). Materials and methods: Patients with surgically proven IDGC (n=85) and benign GB diseases (n=100) were retrospectively enrolled. All patients had preoperative CT and eighty-two patients had US images. Two radiologists independently assessed image findings and analyzed findings suggestive of IDGC and recurrence after surgery. Univariate and multivariate analyses were performed to identify significant predictors for IDGC and recurrence. RESULTS: 87% (74/85) of IDGC belonged to early cancer. On US, mucosal irregularity (odds ratio (OR), 26.29; 95% confidence interval (CI), 2.66-259.42; p=0.005) was a significant predictor of IDGC. Enhancement pattern of wall (OR, 7.78; 95% CI, 2.84-21.39; p<0.001), and maximum wall thickness (OR, 1.31; 95% CI, 1.11-1.55; p=0.002) were significant predictors of IDGC on CT. Twenty-two patients showed recurrence. For clinical factors, T-, N-stage were associated with recurrence (p<0.001). For imaging, focal wall thickening (OR, 8.74; 95% CI, 1.13-67.49, p=0.038) on US and lymph node enlargement (LNE) (OR, 8.93; 95% CI, 1.44-55.19, p=0.018) on CT were significant predictors of recurrence. CONCLUSION: Image findings are useful to predict IDGC using mucosal disruption, maximum wall thickness, enhancement pattern of wall. In addition, focal wall thickening and LNE were useful for predicting recurrence.
Source: Medical Ultrasonography
DOI: 10.11152/mu-4445
Authors: Jihae An, Jung Hoon Kim, Hee Soo Kim, Jin Sol Choi
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403777723