Work

Harnessing Limb Revascularization With Synthetic Probiotics

Year: 2024

Type: article

Abstract: Peripheral arterial disease (PAD) is a critical vascular condition that results in impaired blood flow leading to chronic limb threatening ischemia (CLTI), tissue necrosis and oftentimes to lower-limb amputation. This is largely due to suboptimal revascularization and inflammatory programs, that fail to instigate neovascularization at sites of vessel stenosis. The incidence of CLTI is on the rise but yet there is a paucity of effective treatment options for patients. We hypothesized that the coordinated action of regenerative angiogenesis and immunosurveillance would likely stimulate effective revascularization in the ischemic leg.

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2024.100231