Year: 2024
Type: article
Abstract: Matrix metalloproteinases (MMPs) have a robust proteolytic activity and play a fundamental role in degradation of extracellular matrix proteins. This degradation is a hallmark of the initiation, progression, and rupture of abdominal aortic aneurysms (AAAs). We hypothesized that broad inhibition of MMPs with a third-generation MMP inhibitor (GM6001) can reduce AAA inflammation and rupture using an established rat model. Our study aimed to investigate the potential of GM6001 in reducing AAA-related inflammation using a rat model, filling a critical gap in AAA research.
Source: JVS Vascular Science
Authors: Mohamed Zaghloul, Santiago Elizondo-Benedetto, Batool Arif, Gyu Seong Heo, Hannah Luehmann, Yongjian Liu, Robert J. Gropler, Mehran M. Sadeghi, Mohamed A. Zayed
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4403778855