Work

Different surgical methods for FIGO stage IVB cervical cancer patients receiving chemotherapy: a population-based study

Year: 2024

Type: article

Abstract: Objective: To assess survival differences between non-extensive surgery (NES) and extensive surgery (ES) in International Federation of Gynecology and Obstetrics (FIGO) stage IVB cervical cancer patients receiving chemotherapy from a population-based database, the Surveillance, Epidemiology and End Results.Methods: Propensity matching was conducted to minimize heterogeneity.Survival analysis was performed by the Kaplan-Meier method, log-rank test, and Cox proportional hazards model.Results: A total of 154 patients met screening criteria, among whom 84 patients (84/154) underwent NES while 70 patients (70/154) underwent ES.After matching, no survival advantage was observed in ES group compared with NES group (p=0.066;hazard ratio [HR]=1.54;95% confidence interval [CI]=0.97-2.42).Stratified analyses suggested ES prolonged overall survival in patients with histology other than squamous cell carcinoma and adenocarcinoma (p=0.028;HR=0.36; 95% CI=0.15-0.89)and American Joint Committee on Cancer (AJCC) T stage T1 (p=0.009;HR=0.18; 95% CI=0.05-0.66).Despite no survival benefit after regional lymph node surgery (p=0.629;HR=0.88; 95% CI=0.53-1.47),subgroup analyses demonstrated that patients younger than 50 (p=0.006;HR=0.21; 95% CI=0.07-0.64),with AJCC T stage T1 (p=0.002;HR=0.09; 95% CI=0.02-0.42),T3 (p=0.001;HR=0.02; 95% CI=0.00-0.21),hematogenous metastasis (p=0.036;HR=0.27; 95% CI=0.08-0.92)and without surgery of other sites (p=0.040;HR=0.01; 95% CI=0.00-0.79)might achieve longer survival after regional lymph node surgery.Conclusion: In conclusion, ES or regional lymph node surgery may provide survival advantage for certain subgroup of FIGO IVB cervical cancer patients receiving chemotherapy.However, it deserves large scale prospective clinical trials to confirm.

Source: Journal of Gynecologic Oncology

DOI: 10.3802/jgo.2025.36.e42

Authors: Haoran Li, Jiao Wu, Qing Xu, Yixin Chen, Xi Cheng

Institutions: Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Fudan University

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403779613