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Pyoderma Gangrenosum-like Ulcers Associated Granulomatosis with Polyangiitis

Year: 2024

Type: article

Abstract: Granulomatosis with polyangiitis is an ANCA-positive vasculitis primarily affectingsmall to medium-sized vessels, typically involving the lungs and kidneys. This articlepresents a remarkable case of a patient with an unusual pyoderma gangrenosum-likeulcer on the face and granulomatosis with polyangiitis. A 28-year-old man, previouslydiagnosed with granulomatosis with polyangiitis, presented at a dermatology clinic with a 6-month-old ulcer in the right preauricular region following a traumatic incident. A spindle biopsy revealed suppurative granulomatous dermatitis with secondary vascular damage, while cultures showed no signs of infection. The patient was subsequently treated with rituximab, leading to a positive clinical response. This case underscores the challenge of diagnosing this rare manifestation of granulomatosis with polyangiitis and suggests that rituximab could be a valuable treatment option.

Source: Case Reports in Clinical Practice

DOI: 10.18502/crcp.v9i1.16822

Authors: Katia Fabiola Avila, Karla López López, María del Coral Durand Muñoz, Judith Guadalupe Domínguez Cherit

Institution: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403781447

FWCI:

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