Work

Application of Mendelian randomization to explore the genetic association between drinking habits of different beverages and sleep disorder

Year: 2024

Type: article

Abstract: Introduction: This study aimed to provide genetic evidence linking drinking habits of different beverages (DHDB) to sleep disorder liability (SDL), potentially informing clinical treatments to improve lifestyle factors. Material and methods: A two-sample Mendelian randomization (MR) method was employed to explore the genetic associations between DHDB and SDL. The DHDB variables studied encompassed alcohol intake (ALI), alcohol intake frequency (ALF), high-frequency drinking with meals (HAL), tea intake (TEAI), coffee intake (COFI), and red wine intake (RWI). The SDL variables analyzed were insomnia (INS), inhibit excitability (IE), and sleep duration (SD). Results: (IVW) > 0.05). Conclusions: Alcohol intake may elevate insomnia risk without affecting daytime sleepiness or sleep duration. Frequent alcohol consumption may lead to daytime sleepiness and reduced sleep duration but not insomnia. Alcohol with meals might reduce insomnia and daytime sleepiness while improving sleep duration. Tea appears unlinked to insomnia and may reduce daytime drowsiness. Coffee may alleviate daytime drowsiness without causing insomnia, and red wine shows no significant association with sleep disorders. Reverse MR suggests potential links between sleep disorders and alcohol or caffeine intake.

Source: Archives of Medical Science

DOI: 10.5114/aoms/193054

Authors: Chao Zhang, Xiaoxun Du

Institutions: Guangzhou University of Chinese Medicine, Tianjin University of Traditional Chinese Medicine

Language: English

Topic: Sleep and related disorders

Subfield: Experimental and Cognitive Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,078