Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31‐year follow‐up
Year: 2024
Type: article
Study design: Observational Study
Abstract: Evidence is accumulating on the connection of early adversities and harsh family environment with epigenetic ageing. We investigated whether early psychosocial resilience is associated with epigenetic ageing in adulthood. We used the population‐based Young Finns data (n = 1593). Early psychosocial resilience was assessed in 1980–1989 across five broad domains: (1) index of psychological strength (self‐esteem at home/in general/at school, perceived possibilities to influence at home, internal life control), (2) index of social satisfaction (perceived support from family/friends and life satisfaction), (3) index of leisure time activities (hobbies and physical fitness), (4) index of responsible health behaviors (infrequent smoking or alcohol consumption), and (5) index of school career (school grades and adaptation). Epigenetic ages were calculated for blood samples from 2011, and the analyses were performed with variables describing age deviation (AgeDevHannum, AgeDevHorvath, AgeDevPheno, AgeDevGrim) and DunedinPACE. Covariates included early family environment, polygenic risk scores for schizophrenia and major depression, adulthood education, and adulthood health behaviors. All of the early resilience indexes were associated with lower levels of epigenetic ageing in adulthood, most consistently with AgeDevGrim and DunedinPACE. The associations of psychological strength and social satisfaction, in particular, seemed to be non‐linear. In a smaller subsample (n = 289), high early resilience was related to lower AgeDevGrim over a 25‐year follow‐up in those who had high “baseline” levels of AgeDevGrim. In conclusion, early resilience seems to associate with lower level of epigenetic ageing in adulthood. Our results tentatively suggest that early resilience may increase “equality in epigenetic ageing” in a general population.
Source: Aging Cell
DOI: 10.1111/acel.14394
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,350
Funders: Yrjö Jahnssonin Säätiö, European Commission, Kela, Academy of Finland, Suomen Kulttuurirahasto, Jane ja Aatos Erkon Säätiö, Juho Vainion Säätiö, Signe ja Ane Gyllenbergin Säätiö, Emil Aaltosen Säätiö, Sydäntutkimussäätiö, Tampereen Tuberkuloosisäätiö, Diabetesliitto, Paavo Nurmen Säätiö, Tays, Syöpäsäätiö, Suomen kliinisen kemian yhdistys, H2020 European Research Council
Awards: G1000894810, G1037428335, G1255523522, G1483795045, G1595023581, G1601895641, G1661165, G1686171937, G1763104746, G1872575776, G1891033315, G2230772921, G2330237237, G2484100823, G2513778610, A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities, G3111916513, G3213590351, G33539551, Improving the early prediction of cardiovascular diseases by developing novel data-driven machine learning and multiomics approaches, G3582688621, G3858258543, G4351223834, G4530067370, G4655867613, Life-long stability, heritability and responsiveness of short non-coding RNA levels in relation to the risk of cardiometabolic diseases, G4965406020, G5090981026, G5208171454, G523551622, G5474452856, G5512925732, G5646563246, Life-long stability, transgenerational heritability and responsiveness of circulatory and sperm short non-coding RNAs in relation to the risk of cardiometabolic diseases, G5770909501, G6164432047, G6310393984, G6654874900, G692875121, G69797456, Lifelong and transgenerational epigenetic profiles in relation to the development of cardiometabolic diseases
OpenAlex ID: W4403793514