The Growth Inhibition Effect of Different Extracts of Taraxacum Peregrinum Leaves on Breast Cancer Cell Line MDA-MB-468
Year: 2024
Type: article
Abstract: Background and Objectives: The dandelion plant (Taraxacum officinale) is one of the plants with beneficial effects. In this study, we evaluated the growth inhibition of different extracts of Iranian dandelion (Taraxacum peregrinum) on breast cancer cells. Methods: Ethanolic, methanolic, hydroalcoholic, and aqueous extracts and juice of dandelion leaves were first prepared by the Maceration method. Seven concentrations (0.01, 0.1, 1, 10, 100, 1000, and 10000 mg/mL) were prepared from different extracts. Cisplatin was used as a standard anticancer drug. Their half-maximal inhibitory concentration (IC50) values were evaluated by the MTT assay. Data analysis was done in Excel and GraphPad Prism 8.0.2 software. Results: By increasing the concentration of different extracts, the growth inhibitory effect on cancerous cells increased after 72 hours of exposure. The greatest growth inhibition effect was shown by ethanolic extract (IC50=0.75±0.31 mg/mL) after 72 hours of exposure followed by methanolic extract (IC50=6.25±0.76 mg/mL) and aqueous extract (IC50=6.59±0.94 mg/mL). Their effects were much more significant and better than Cisplatin (IC50=42.57±1.73 mg/mL). However, hydroalcoholic extract and juice of dandelion leaf did not show a significant growth inhibition effect. Conclusion: Given the significant effects of ethanolic, methanolic, and aqueous extracts of Taraxacum peregrinum leaves on inhibiting the growth of the MDA-MB-468 breast cancer cell line, this plant can be used as an herbal supplement for the treatment of breast cancer.
Source: Qom Univ Med Sci J
Authors: Hoda Abolhasani, Ahmad Abolhasani, Fatemeh Nojavan, Mahdieh Ghahremani, Fatemeh Heidari
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4403797457