Association of human leucocyte antigen loci with vaccine‐induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4‐derived peptides and MHC ‐ II
Year: 2024
Type: article
Study design: Observational Study
Abstract: No risk factors have been identified for vaccine-induced immune thrombotic thrombocytopenia (VITT) so far. The aim of this study was to identify human leucocyte antigen (HLA) alleles potentially associated with VITT susceptibility. Specific HLA class II alleles were detected with significantly higher frequency in VITT patients compared with Italian controls: DPB1*17:01, DQA1*05:01, and DRB1*11:04. In silico analysis revealed increased affinity of DRB1*11:04 for a platelet factor 4 (PF4)-derived peptide, ITSLEVIKA, that contains two amino acids present in the specific binding site of anti-PF4 antibodies from VITT patients. Our findings show for the first time a genetic predisposition to developing anti-PF4 antibodies in response to Ad-vector vaccines.
Source: British Journal of Haematology
DOI: 10.1111/bjh.19838
Authors: Eleonora Petito, Loredana Bury, Lilian Antunes Heck, Brooke Sadler, Erica De Candia, Gian Marco Podda, Anna Falanga, Lucia Stefanini, Andrea Boccatonda, Patrizia Sciancalepore, Igor Florio, Egidio Imbalzano, Rossella Marcucci, Patrizia Noris, Marta Panella, Rita Carlotta Santoro, Maria Costanza Turi, Gaetano Vaudo, Jorge Di Paola, Matthew T. Rondina, Paolo Gresele
Institutions: University of Perugia, Washington University in St. Louis, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, University of Milan, Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo, Ospedale Papa Giovanni XXIII, Sapienza University of Rome, Azienda USL di Bologna, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Ospedale di Bolzano, Azienda Sanitaria dell'Alto Adige, University of Messina, University of Florence, University of Pavia, Policlinico San Matteo Fondazione, University of Rome Tor Vergata, Azienda Ospedaliera Pugliese Ciaccio, Ospedale SS. Annunziata, University of Utah, University of Utah Health Care, George E. Wahlen Department of VA Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,940
OpenAlex ID: W4403802497