Mendelian Randomization Study of the Causal Relationship between PM2.5 and Neurodegenerative Diseases
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: In recent years, a large number of studies have evaluated the relationship between particulate matter 2.5 (PM2.5) and the incidence rate and mortality of neurodegenerative diseases (NDDs), but the conclusion is controversial. Methods: The publicly available statistical data from genome-wide association studies were used for two sample MR. Inverse variance weighted is used as the main analysis, MR Egger regression, maximum likelihood, simple median, and weighted median are used for supplementary validation. Results: MR analysis results indicate that for every standard deviation increase in PM2.5 exposure, the risk of Alzheimer's disease (AD) increases by 41% (95% CI: 1.10～1.82, P=0.008). However, there is no causal association between PM2.5 and NDDs such as Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Dementia with Lewy bodies. Sensitivity analysis did not detect heterogeneity and pleiotropy, indicating that the analysis results are robust. Conclusion: There is a causal relationship between PM2.5 and the risk of AD, and reducing PM2.5 exposure may be of great significance for the prevention of AD.
Authors: Xiaohong Liu, Meiyu He, Guibin Wang
Institution: Hunan Normal University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4403806743