Work

Pathognomonic Features of Olmesartan-Induced Collagenous Sprue Resulting in Severe Small Bowel Malabsorption

Year: 2024

Type: article

Abstract: Collagenous sprue (CS) is a rare autoimmune gastrointestinal disorder characterized by specific histologic changes in the small intestine. It often presents with more severe symptoms and a worse prognosis compared to celiac disease, including significant malabsorption, weight loss, and nutrient deficiencies. Despite treatment with a gluten-free diet, symptom improvement is limited, with only a small fraction of patients responding positively. This case report highlights the diagnostic challenges and clinical features of CS in a 74-year-old woman, whose symptoms resolved following cessation of olmesartan. The case emphasizes the importance of recognizing medication-induced forms of the disease and outlines the need for targeted management strategies to improve patient outcomes.

Source: Cureus

DOI: 10.7759/cureus.72571

Authors: McKennah A Goshgarian, Jeffrey Laczek, Michael Lustberg

Institutions: Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Sutter Santa Rosa Regional Hospital

Language: English

Topic: Celiac Disease Research and Management

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403822753