Year: 2024
Type: article
Abstract: Despite the numerous published syntheses and applications of sulfoximines, very few studies describe their physico‐chemical properties and in particular their acidic, basic and lipophilic or hydrophilic characters. We report for the first time the acidity values (p K a ) of fluorinated sulfoximines in water and in acetonitrile, as well as the basicity (p K aH ) measurements of fluorinated and non‐fluorinated sulfoximines in acetonitrile. The same sulfoximine library was also studied in terms of lipophilicity with measurement of the Hansch parameters of the sulfoximine moieties. Finally, these new data allowed us to optimize the N ‐alkylation reaction of fluorinated sulfoximines.
Source: Chemistry - A European Journal
Institutions: Université de Tours, Centre National de la Recherche Scientifique, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Lavoisier de Versailles, Physico-Chimie des Matériaux et des Électrolytes pour l’Énergie, Tartu University Hospital, University of Tartu, Lyon 1 Université, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, École d'Ingénieurs en Chimie et Sciences du Numérique
Language: English
Topic: Chemical Reaction Mechanisms
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4403824538