Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias
Year: 2024
Type: article
Study design: Observational Study
Abstract: γδ-T cells expansion correlates with treatment efficacy validated in a cohort of B-ALL (n = 18) and diffuse large B cell lymphoma (DLBCL) patients (n = 58). Our data provide insights into the complexity of T cell responses following CAR-T cell therapy and suggest drivers of immunotherapy response.
Source: Cell Reports Medicine
Authors: Mercedes Guerrero-Murillo, Aina Rill-Hinarejos, Juan L. Trincado, Alex Bataller, Valentín Ortiz-Maldonado, Daniel Benítez-Ribas, Marta Español-Rego, E Azucena González-Navarro, Nuria Martínez-Cibrián, Doménica Marchese, Lourdes Martín-Martín, Alejandro Martín García-Sancho, Susana Rives, Holger Heyn, Manel Juan, Álvaro Urbano-Ispizúa, Julio Delgado, Alberto Orfao, Elisabetta Mereu, Clara Bueno, Pablo Menendez
Institutions: Josep Carreras Leukaemia Research Institute, Universitat de Barcelona, Hospital Clínic de Barcelona, Instituto de Salud Carlos III, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Universidad de Salamanca, Instituto de Investigación Biomédica de Salamanca, Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer de Salamanca, Centro de Investigación Biomédica en Red de Cáncer, Hospital Sant Joan de Déu Barcelona, Institut de Recerca Sant Joan de Déu, Institució Catalana de Recerca i Estudis Avançats
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,460
Awards: G1175115578, G2064873908, RNA PROCESSING FOR ANTI-CANCER IMMUNOTHERAPY, G2262748287, G24120701, G2601397997, G294895050, G3005324705, G300979063, G3480869486, G3681454997, G4042783231, G425668148, CD22/CD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia, Clinical translation of a novel CD1a-directed CAR for relapse/refractory cortical T-cell Acute Lymphoblastic Leukemia: feasibility, efficacy and safety, G4937468798, G5080475149, G5195188938, G6656126374, G683931746, G7084143925, G7340230215, G787121397
OpenAlex ID: W4403825098