Work

Ion channel Piezo1 induces ferroptosis of trabecular meshwork cells: a novel observation in the pathogenesis in primary open angle glaucoma

Year: 2024

Type: article

Abstract: This study is the first to show that cell stretching induces ferroptosis in trabecular meshwork cells (TMCs), dependent on Piezo1 activation. Targeting the Piezo1 pathway offers new therapeutic potential for mitigating trabecular meshwork dysfunction and managing primary open angle glaucoma (POAG). The study also reveals Piezo1 induces ferroptosis via the JNK/p38 signaling pathway.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00173.2024

Authors: Kexin Liu, Jing Xu, Rufei Yang, Feng Wang, Ying Su

Institutions: Harbin Medical University, Fourth Affiliated Hospital of Harbin Medical University, First Affiliated Hospital of Harbin Medical University

Language: English

Topic: Glaucoma and retinal disorders

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Natural Science Foundation of Heilongjiang Province, Heilongjiang Provincial Science and Technology Department