Work

Synthesis of benzo[ f ]quinazoline-1,3(2 H ,4 H )-diones

Year: 2024

Type: article

Abstract: We report the synthesis of polycyclic uracil derivatives. The method is based on palladium-catalysed Sonogashira-Hagihara and Suzuki-Miyaura cross-coupling reactions followed by Brønsted acid-mediated cycloisomerisation. The developed methodology tolerates various functional groups and leads to moderate up to quantitative yields of the final products. The impact of different functional groups on the optical properties was studied by UV-vis and fluorescence spectroscopy.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.20.228

Authors: Ruben Manuel Figueira de Abreu, Peter Ehlers, Peter Langer

Institution: University of Rostock

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Universität Rostock, Leibniz-Gemeinschaft

OpenAlex ID: W4403835775