Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott
Year: 2024
Type: article
Abstract: Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-3, 6, and 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).
Source: Molecules
Authors: Xu Chen, Yangang Cao, Kaili Ye, Yanling Liu, Fangge Chi, Ying Niu, Di Lu, Bingxian Zhao, Lan Chen, Xiaoke Zheng, Weisheng Feng
Institution: Henan University of Traditional Chinese Medicine
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,069
OpenAlex ID: W4403837252