Work

Mapping Alzheimer’s disease: exploring cellular vulnerability and resilience

Year: 2024

Type: article

Abstract: In a recent paper published in Nature, Mathys and co-workers presented a comprehensive and precise transcriptomic atlas of distinct brain regions from individuals with and without Alzheimer’s disease (AD). This paper aimed to identify differences in regional molecular architecture along with region-specific changes in neuronal and glial subtypes, while also investigating whether certain brain regions and cell subtypes are more vulnerable or uniquely affected by AD compared to others, and exploring mechanisms that may contribute to cellular resilience. 1

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-024-02014-9

Authors: Natalia Ortí-Casañ, John R. Bethea, Ulrich L. M. Eisel

Institutions: University of Groningen, George Washington University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,490