Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic
Year: 2024
Type: article
Abstract: BACKGROUND: Inflammaging and physical performance were investigated in older adults before and after the COVID-19 pandemic. METHODS: = 7) (mean age = 73.8 ± 7.1) were evaluated before the COVID-19 pandemic (PRE), 12 months after the lockdown (POST), and 10 months after resuming exercise training (POST-TR). Physical tests [gait speed (GS) and timed-up-and-go (TUG)]; muscle strength (handgrip-HG); and serum cytokine levels were assessed. RESULTS: Older women showed higher GS and TUG at POST than PRE and POST-TR but lower HG at POST-TR than PRE, whereas older men exhibited lower HG at POST and POST-TR than PRE. Both groups presented (1) lower IL-10 and IL-12p70 values in contrast to higher IL-6/IL-10 and IL-8/IL-10 ratios at POST than PRE; (2) higher IL-10 values and lower IL-8/IL-10 ratio at POST-TR than POST; (3) higher IL-12p70/IL-10 ratio at POST-TR than PRE and POST. Particularly, older women showed (4) lower IL-6 values at POST and POST-TR than PRE; (5) lower IL-8 and IL-10 values at POST-TR than POST; (6) and higher TNF-α/IL-10 and IFN-γ/IL-10 ratios at POST than PRE and POST-TR. Significant correlations between the variables were found in both groups. DISCUSSION: During the COVID-19 pandemic, detraining and resumption of exercise training promoted distinct alterations in physical capacity and inflammaging among older women and older men.
Authors: Carlos André Freitas dos Santos, Ariane Nardy, Renato Jimenez Gomes, Brenda Rodrigues Silva, Fernanda Rodrigues Monteiro, Marcelo Rossi, Jônatas Bussador do Amaral, Vitória Paixão, Mauro Walter Vaisberg, Gislene Rocha Amirato, Rodolfo P. Vieira, Juliana de Melo Batista dos Santos, Guilherme Eustaquio Furtado, Ana Paula Ribeiro, Patrícia Colombo-Souza, Alessandro Ferrari Jacinto, Andre Luis Lacerda Bachi
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,842
Awards: Impact of Cytomegalovirus (CMV) seropositivity and microbiota profile on the immune/inflammatory response both systemic and in the upper airways of elderly vaccinated for respiratory diseases, Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine, G3711243930, G4431886633, G4632206156, G5572950167, G6419119844, G704622720, G8089844501
OpenAlex ID: W4403844749