Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 cells with gut tropism
Year: 2024
Type: article
Abstract: Activated CD4 + T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4 + T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR activated dendritic cells (DCs) is unknown. Here, we show that the combined activation through TLR2, which alone does not induce a clear Th polarization, and TLR4, which alone does not imprint mucosal tropism, equip non-mucosal DCs to prime gut-homing CD4 + T cells with reinforced Th1 polarization. These results show that targeting DCs with combined innate stimuli with distinct properties is a rational strategy to program the outcome of T cell polarization and simultaneously control their tissue tropism. Exploring this strategy could enhance the efficacy of vaccines and immune cell therapies.
Source: iScience
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,150
Awards: G1120915301, Activação via TLR2 para o desenvolvimento de melhores vacinas veterinárias, Centro de Investigação Interdisciplinar em Sanidade Animal, Programação do tipo e localização de imunidade adaptativa com base na estimulação de TLR2: uma estratégia para o desenvolvimento de novas vacinas veterinárias, G2297712793, G2928568735, Laboratório Associado para Ciência Animal e Veterinária, G5454278309, G7532796743, Centro de Investigação Interdisciplinar em Sanidade Animal
OpenAlex ID: W4403847341