Post-mastectomy hypofractionated versus conventionally fractionated radiation therapy for patients receiving immediate breast reconstruction: Subgroup analysis of a phase III randomized trial
Year: 2024
Type: article
Abstract: Post-mastectomy radiation therapy (PMRT) has been proved to improve loco-regional control, and disease-free survival (DFS) for patients with large tumors and/or positive axillary nodes [1,2]. Despite the oncological benefits, numerous studies have shown that PMRT using conventional fractionation confers negative impact on reconstructed breasts in the setting of immediate breast reconstruction (IBR) [3–6]. As compared to conventionally fractionated (CF)- PMRT, a moderately hypofractionated (HF)- regimen is demonstrated to provide equivalent disease control for patients with high-risk breast cancer in a randomized phase 3 trial [7,8].
Institutions: Fudan University, Fudan University Shanghai Cancer Center
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,130
OpenAlex ID: W4403847694