Work

Hydroxyapatite in Oral Care Products: In vitro Effects on Erosion/Abrasion and Analysis of Formulation Components

Year: 2024

Type: article

Abstract: INTRODUCTION: Hydroxyapatite (HAP) is promoted as biomimetic material in dentistry. The aim of the study was to investigate whether HAP-containing formulations can reduce erosive/abrasive tissue loss and to analyse components in these formulations. METHODS: Two HAP toothpastes with and two without fluoride and a HAP mouthrinse were investigated, controls were active agent-free toothpaste, SnF2 toothpaste and F/Sn mouthrinse. For 10 days, human enamel samples were eroded for 2 min, 6×/day in 0.5% citric acid and immersed for 2 min, 2×/day in toothpaste slurries or mouthrinse. Half were additionally brushed for 15 s, 2×/day. The particulate fraction was extracted and examined morphologically and with element analyses. Other parameters were REA, RDA, fluoride and calcium content. RESULTS: The F/Sn mouthrinse almost completely prevented tissue loss; none of the HAP formulations reduced tissue loss compared to the negative control, two increased it instead. Brushing increased tissue loss in all groups except the F/Sn mouthrinse. All toothpastes contained amorphous particles of different sizes. Elemental analysis identified Si and O, and additionally, Ca and P were present in small amounts on the particles of the HAP toothpastes and one HAP+F toothpaste. In the liquid phase, elevated calcium levels were found in one HAP toothpaste and in both HAP+F toothpastes; in the formulation with the highest value, the fluoride concentration was low. REA and RDA values were not associated with tissue loss. CONCLUSIONS: Whether alone or in combination with fluoride, HAP formulations had either no or a detrimental effect on erosive tissue loss and could not reduce abrasion. In the context of erosive tooth wear, HAP seems to be neither an alternative to fluoride nor a suitable supplement to it.

Source: Caries Research

DOI: 10.1159/000542178

Authors: Katja Jung, Peter Kerzel, Anderson T. Hara, Benedikt Luka, Nadine Schlueter, Carolina Ganss

Institutions: Philipps University of Marburg, Justus-Liebig-Universität Gießen, Indiana University Indianapolis, Medizinische Hochschule Hannover

Language: English

Topic: Dental Erosion and Treatment

Subfield: Orthodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4403850348