Wound healing activity of Ipomoea staphylina leaves extract in Wistar rats
Year: 2024
Type: article
Abstract: Wound repair is the practice of repairing the skin and other soft tissues after an injury. An inflammatory response is activated after an injury, and cells below the dermis (deepest skin layer) begin to produce more collagen (connective tissue). A scientific assessment was made for the wound-healing potential of Ipomoea staphylina leaves extract, using ethanol. The crude extract was made into a 2.5% and 5% (w/w) ointment and tested for wound healing activity in Wistar rats using excision and incision wound models. In the excision wound model, the period of epithelialization was reduced and an increase in wound contraction rate was observed in the extract treated groups (III and IV). On the tenth day, tissue from the excision wound area was taken and processed for the assessment of pro-inflammatory cytokines (TNF-α), and it was found that there was a notable decrease in the TNF-α concentration in the extract-treated animals. In an incision wound model, the breaking strength was significantly increased in animals treated with 2.5% and 5% (w/w) ointment of I. staphylina leaves extract. The extract significantly promoted fibroblast migration in an in vitro experiment (scratch assay), which may have been caused by the presence of flavonoids.
Source: BioResources
Authors: Manjun Lu, Hongchao Yang, Na Yang, Jun Peng, Xiuli Hou
Institution: Qilu Hospital of Shandong University
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,452
OpenAlex ID: W4403860711