Mediators of the association between educational attainment and carpal tunnel syndrome: A 2-sample, 2-step Mendelian randomization study
Year: 2024
Type: article
Study design: Observational Study
Abstract: To clarify the causal relationship and potential mediators between educational attainment and carpal tunnel syndrome (CTS), as well as to evaluate whether educational attainment, cognition, and intelligence independently exert causal effects on CTS, we employed univariable Mendelian randomization (MR), multivariable MR, reverse MR, and 2-step MR approaches. Our research demonstrates that educational attainment exerts an independent causal effect on CTS, with this causal relationship being unidirectional. Five mediators were identified as significant influencers within the causal pathways connecting educational attainment and CTS. Targeting these mediators may be beneficial in the prevention of CTS.
Source: Medicine
Authors: Yunrong Lai, Weiquan Hu, Suping Hu, Qinglin Liu, Xianping Huang, Qinfei Zhao
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,950
OpenAlex ID: W4403867134