Work

Towards the prediction of plaque onset and growth in carotid arteries

Year: 2024

Type: article

Abstract: We describe a computational platform to predict atherosclerotic plaque onset and growth in carotids.It integrates in-vivo data, Computational Fluid Dynamics (CFD) simulations and a model for plaque growth linearly correlating the plaque progression with low values of time-averaged Wall Shear Stresses (WSS).We show that steady CFD simulations give the same averaged-WSS values as unsteady simulations.Therefore, the model for plaque growth can be coupled with steady simulations, reducing the computational costs.Finally, by comparing the numerical predictions with the in-vivo data, we show that a modification must be introduced in the plaque growth model to obtain acceptable results.

Source: Journal of Theoretical and Applied Mechanics/Mechanika Teoretyczna i Stosowana

DOI: 10.15632/jtam-pl/191182

Authors: Jaskaran Singh, Katia Capellini, Benigno Marco Fanni, Alessandro Mariotti, Maria Vittoria Salvetti, Simona Celi

Institutions: University of Pisa, Fondazione Toscana Gabriele Monasterio

Language: English

Topic: Cerebrovascular and Carotid Artery Diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Università di Pisa