A Sustainable Approach for Palladium and Phosphane‐Free Sonogashira Type Cross‐Coupling of 2‐Chloroquinoline with Terminal Alkynes
Year: 2024
Type: article
Abstract: An efficient and cost‐effective Cu (I) mediated protocol for the C(sp 2 )–C(sp) cross‐coupling of 3‐chalcone‐2‐chloroquinoline with terminal alkynes has been disclosed by optimizing a wide range of catalysts, ligands, base, and solvents. This approach conveniently assembles various alkynylated hybrids with excellent to moderate yields. Appropriate functional group tolerance and significant mechanistic pathway with mild reaction conditions well‐justified this synthetic transformation more sustainable towards the greener exploration.
Source: ChemistrySelect
Authors: Zebabanu Khalifa, Amit B. Patel
Institution: Veer Narmad South Gujarat University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4403881384