Year: 2024
Type: article
Abstract: An umpolung strategy for the C(sp3)−H aminomethylation of 2‐methylindole has been developed using trifluoroacetic acid to induce the transformation, with aminals serving as precursors of iminium ion. Mechanistic studies have clearly shown that trifluoroacetic acid may play a pivotal role in this strategy. The utilization of readily available starting materials, mild reaction conditions, tolerance to complex functional groups, combine with yields of up to 98% and potential biological applications render this protocol applicable and useful for organic synthesis and medicinal chemistry.
Source: Advanced Synthesis & Catalysis
Authors: Hongmei Kong, Kuo Li, Jingfa Zhang, Hua Yan, Lisha Jing, Yuyin Liu, Chenggang Song, Pan Zhou, Bin Wang
Institution: Weifang Chinese Medicine Hospital
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4403881530