Work

Calcium(II)‐Catalyzed Synthesis of Sulfoximinocyclopentenones

Year: 2024

Type: article

Abstract: A series of 4‐sulfoximinocyclopent‐2‐en‐1‐ones was prepared in 35 to 99% yield through a calcium(II)‐catalyzed aza‐Piancatelli reaction, including in enantioenriched form. Depending on their substitution pattern, diverse diastereoselective chemical transformations can be applied to these scaffolds, allowing access to cyclopentane derivatives. This study opens synthetic routes to cyclopentane‐based scaffolds and also paves the way for the exploration of the associated chemical space in drug discovery.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401085

Authors: Xiangmeng Chen, Christophe Bour, Emilie Kolodziej, Régis Guillot, Nicolas S. George, Aurélien Alix, Vincent Gandon

Institutions: Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

OpenAlex ID: W4403881619

FWCI: 0.417

Cites: 98

Cited by: 3

Related to: 10