Figure 3 from A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples
Year: 2024
Type: other
Abstract: Comparison of gene expression of CU-ACC cell lines and original PDXs. A, Overall correlation between gene expression in the cancer cell lines evaluated at the NCI and CU and their corresponding PDXs. Areas shaded in gray highlight the grouping of corresponding ACC cell lines and PDXs. B, Examples of coherent genes. Univariate analysis scatterplot of ABCB1 (MDR1) transcriptional expression level vs. ABCG2 (BCRP) and CYP21A2 transcriptional expression level vs. CYP11B1 transcriptional expression level. C, Example of differentially expressed genes related to cellular proliferation for the CU-ACC1 and CU-ACC2 cell lines and corresponding PDXs.
Authors: Yasuhiro Arakawa, Fathi Elloumi, Sudhir Varma, Prashant Khandagale, Ukhyun Jo, Suresh Kumar, Nitin Roper, William C. Reinhold, Robert W. Robey, Naoko Takebe, Michael M. Gottesman, Craig J. Thomas, Valentina Boeva, Alfredo Berruti, Andrea Abate, Mariangela Tamburello, Sandra Sigala, Constanze Hantel, Isabel Weigand, Margaret E. Wierman, Katja Kiseljak-Vassiliades, Jaydira Del Rivero, Yves Pommier
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4403886926