Figure 6 from A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples
Year: 2024
Type: other
Abstract: Examples of gene copy number variations and mutations in the ACC cell lines. A, CU-ACC1 is defective in CDKN2A. Univariate scatterplot of CDKN2A transcriptional expression levels vs. CDKN2A gene copy number in the ACC NCI cell line data set. B, Gene mutations in the ACC cell lines; mutation scores were collected from the Colorado, Zurich, and Wurzburg datasets and plotted; CU-ACC2, MUC-1 and JIL-2266 are homozygous TP53 mutants, CU-ACC1 and H595R exhibit heterozygous β-catenin (CTNNB1) mutations. C, CU-ACC2 harbor homozygous NF1 gene mutation and heterozygous NF2 gene mutation in the ACC NCI cell line data set.
Authors: Yasuhiro Arakawa, Fathi Elloumi, Sudhir Varma, Prashant Khandagale, Ukhyun Jo, Suresh Kumar, Nitin Roper, William C. Reinhold, Robert W. Robey, Naoko Takebe, Michael M. Gottesman, Craig J. Thomas, Valentina Boeva, Alfredo Berruti, Andrea Abate, Mariangela Tamburello, Sandra Sigala, Constanze Hantel, Isabel Weigand, Margaret E. Wierman, Katja Kiseljak-Vassiliades, Jaydira Del Rivero, Yves Pommier
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4403886953