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PGC1α in Skeletal Muscle Mediates Anti-Obesity Effects of Soy Isoflavones

Year: 2024

Type: article

Abstract: Obesity, a factor increasing the risk of metabolic diseases such as type 2 diabetes, dyslipidemia, and hypertension, can be reduced by the intake of soy isoflavones. In this study, we investigated whether skeletal muscle PGC1α, a transcriptional activator known to promote a variety of exercise-related metabolic processes, is involved in the anti-obesity effects of soy isoflavones using skeletal muscle-specific PGC1α knockout mice. The results showed that the intake of soy isoflavones reduced white adipose tissue weight and increased expression of energy metabolism-related genes such as mitochondrial function, lipolysis, and fatty acid oxidation in skeletal muscle. However, these effects were not observed in skeletal muscle-specific PGC1α knockout mice. In C2C12 myoblasts with overexpressing PGC1α, soy isoflavone treatment increased energy-metabolism related genes. Therefore, PGC1α of skeletal muscle is likely to be involved in the anti-obesity effects of soy isoflavones.

Source: Journal of Nutritional Science and Vitaminology

DOI: 10.3177/jnsv.70.434

Authors: Takumi SUGIMOTO, Tokushi KIMURA, Mamoru OYABU, Ran UCHITOMI, Shiho NAKAI, Yasutomi KAMEI

Institution: Kyoto Prefectural University

Language: English

Topic: Phytoestrogen effects and research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: diamond

Funders: Life Sciences Research Foundation, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science