Work

Epigenetic alterations in oral cancer: Mechanisms, biomarkers, and therapeutic targets

Year: 2024

Type: article

Abstract: Epigenetic alterations play an important aspect in the pathogenesis of oral cancer, affecting gene regulation occurs without altering the DNA sequence itself. These alterations include processes like DNA methylation , histone modification , and the regulation mediated by non-coding RNAs (ncRNAs), contribute to the initiation, progression, and metastasis of oral squamous cell carcinoma (OSCC). This review comprehensively examines the major epigenetic mechanisms implicated in oral cancer, elucidates potential biomarkers for early detection and prognosis, and explores emerging epigenetic therapies with significant potential for targeted treatment . The reversible characteristics of epigenetic modifications render them promising therapeutic targets and offers hope for improved clinical outcomes. We also discuss the current limitations in research and suggest future directions for developing effective epigenetic-based diagnostic and therapeutic strategies.

Source: Oral Oncology Reports

DOI: 10.1016/j.oor.2024.100681

Authors: Madhan Krishnan, Sharan Basappa, Shyamaladevi Babu

Institutions: Chettinad Academy of Research and Education, Malla Reddy Institute Of Medical Sciences, Malla Reddy Vishwavidyapeeth

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100