Work

Littoral cell angioma of a huge spleen with peripheral blood pancytopenia in a 14-year-old boy: a case report and review of the literature

Year: 2024

Type: article

Abstract: Background: Splenic littoral cell angioma (LCA) is an exceptionally uncommon malignant potential vascular tumor with infrequent occurrences in pediatric patients. Due to its reliance on histopathological analysis for diagnosis, LCA may be mistakenly identified as other splenic tumors. Patients with LCA may experience anemia or thrombocytopenia, but peripheral blood pancytopenia is infrequent. Case report: A 14-year-old boy presented with peripheral blood pancytopenia, necessitating hospitalization after splenomegaly was identified during a physical examination. Following the exclusion of hematological disorders, a splenectomy was conducted; histopathological examination confirmed the diagnoses of LCA. No metastases or recurrences were observed during the 8-month follow-up. To the best of our knowledge, this case represents the first instance of LCA associated with pancytopenia in a pediatric patient. Conclusion: LCA can lead to iron-deficiency anemia or thrombocytopenia, with rare occurrences of pancytopenia, potentially resulting in misdiagnosis as a hematological disorder. Surgical intervention remains an effective treatment for LCA.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2024.1473930

Authors: Tianyu Gao, Xingang Wang, Qiuya Wei, Chen Wang, Yong Fan, Yuebin Wang

Institutions: Lanzhou University Second Hospital, Lanzhou University

Language: English

Topic: Vascular Tumors and Angiosarcomas

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295