Work

Multiomic analysis of Lewisite exposed human dermal equivalent tissues

Year: 2024

Type: article

Abstract: Lewisite (Military Code: L) is an arsenical vesicant chemical warfare agent (CWA) that was developed in the United States during World War I. Even though its use has not been documented in warfare, large stockpiles were created and still exist in various locations around the world. Given that large quantities exist as well as the relative straightforward process for its creation, Lewisite still presents itself as a serious threat agent. In this study, we examined the effects of Lewisite on human dermal equivalent tissues (EpiDerm™/EpiDerm™-FT) through the evaluation of cellular viability, histology, and multiomic analysis. • Exposure to Lewisite reduces dermal cellular viability in a dose- and time-dependent manner. • Lewisite induces a mix of apoptosis and necrosis in human dermal tissue. • Multiomic analysis of human dermal equivalent samples exposed to Lewisite. • Lewisite activates several S100 proteins in human dermal tissue.

Source: Chemico-Biological Interactions

DOI: 10.1016/j.cbi.2024.111295