Work

MELAS syndrome and risk of infection

Year: 2024

Type: article

Abstract: This perspective explores the relationship between mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome and an increased risk of infections. Mitochondrial dysfunction impairs immune cell function, impacting the body’s defense against pathogens. Additional effects on the immune system may manifest through altered B-cell function and disruptions in the gut microbiota balance. The complex connection between infections, MELAS symptoms, and treatment complicates patient management. We propose greater focus on genetic abnormalities and their immunologic impacts, indicating a possible path for targeted pharmaceutical therapies to improve overall illness management.

Source: Emergency and Critical Care Medicine

DOI: 10.1097/ec9.0000000000000130

Authors: Muskaan Saleem, Myra Sohail, Ahmad Akhtar

Institutions: Bahria University, Ziauddin University, Anderson Hospital, Mercy Health

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403970384

FWCI:

Cites: 8

Cited by:

Related to: 10