Work

SPHK1 promotes HNSCC immune evasion by regulating the MMP1-PD-L1 axis

Year: 2024

Type: article

Abstract: Our study reveals a novel role for SPHK1 in mediating immune evasion in HNSCC through the regulation of the MMP1-PD-L1 axis. We identified SPHK1 and MMP1 as predictive biomarkers for the therapeutic response to PD-1 mAb and provided new therapeutic targets for patients with HNSCC.

Source: Theranostics

DOI: 10.7150/thno.102390

Authors: Qi Fang, Xiao Chen, Fei Cao, Pengfei Xu, Zheng Zhao, Roubin Lin, Di Wu, Wuguo Deng, Xuekui Liu

Institutions: Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Anhui Medical University, Second Affiliated Hospital of Anhui Medical University

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4403987345

FWCI: 2.022

Cites: 50

Cited by: 13

Related to: 10