Work

Skin Biopsy Detection of Phosphorylated α‐Synuclein in Patients of Bullous Pemphigoid with or without Parkinson's Disease

Year: 2024

Type: article

Abstract: BACKGROUND: High positivity rate of skin phosphorylated α-synuclein (P-SYN) was observed in Parkinson's disease (PD). Bullous pemphigoid (BP) is one of the most common autoimmune skin diseases associated with PD. OBJECTIVES: Our aim was to investigate whether BP patients might be a targeted risk population for the screening of skin P-SYN. METHODS: Skin P-SYN expression was evaluated by immunohistochemistry in BP patients with/without PD. RESULTS: Twenty-two BP patients with PD, 24 BP patients without PD, and seven healthy donors were enrolled. Colocalization of P-SYN and PGP9.5 was found in all BP patients, but only one healthy control, whereas BP patients with PD showed higher expression than BP patients without PD (mean ± standard deviation, 10.7 ± 6.7 vs. 7.3 ± 3.2; P = 0.027). Positive expression was mainly observed in basement membrane zone and dermis. CONCLUSION: These results indicated BP patients might be a targeted risk population for the screening of skin P-SYN, which was helpful for the detection of PD early. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Source: Movement Disorders

DOI: 10.1002/mds.30045

Authors: Shan Cao, Xiang Fang, Jianwen Wang, Yonghu Sun, Furen Zhang

Institutions: Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,270