Get started
Work

Hematological Indicators as Prognostic Factors for COVID-19 Mortality: Exploring Anemia and Systemic Inflammation

Year: 2024
Type: article
Study design: Observational Study
Abstract: Objectives: In this study, we investigated whether hematological indicators of anemia and systemic inflammation at admission could be a prognostic indicator for hospital mortality of patients with COVID-19. Methods: In this retrospective study, the hematological and inflammatory parameters of 201 patients with COVID-19 were evaluated from June 2020 to October 2021. The associations of hemoglobin (Hb), hematocrit (Hct), red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) and lymphocyte-to-CRP (LCR) with disease severity and mortality were assessed. Moreover, the presence of autoantibodies in serum patients was analyzed using an indirect antiglobulin test (AIT). Results: In comparison to non-ICU-admitted patients, results demonstrated that ICU patients had higher levels of CRP, NLR, PLR and a lower percentage of lymphocyte and LCR within 24 hours of admission, and all patients had negative indirect AIT. High levels of NLR, PLR, and low levels of LCR showed a significant risk for mortality in patients with COVID-19 with hazard ratios (HRs) of 1.967 (95% CI, 1.061%, 3.645%; P=0.032), 1.026 (95% CI, 1.007%, 1.045%) and 1.001 (95% CI, 1.000%, 1.002%), respectively. Also, in ICU-admitted patients, low Hb combined with high RDW predicted mortality with HRs of 3.229 (95%CI, 1.637%, 6.366%) and 4.038 (95% CI, 1.824%, 8.937%, P=0.001), respectively. Discussion: Altogether, the results of this study underline the potential prognostic value of NLR, PLR, LCR, and anemia in COVID-19 patients. However, the study results should be confirmed in a larger sample or prospective clinical study.
DOI: 10.34172/hmj.8286
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W4404009100
FWCI:
Cites:
Cited by:
Related to: 10