Work

Atypical Thyroid Stimulating Hormone Levels in Myxedema Coma Complicated by Severe Sepsis

Year: 2024

Type: article

Abstract: Most cases of Myxedema Coma are associated with primary hypothyroidism characterized by significantly elevated thyroid stimulating hormone (TSH) levels. However, this case presents an atypical manifestation of myxedema coma with low TSH levels despite severe hypothyroidism. The rarity of this presentation lies in the absence of central lesions typically responsible for such TSH suppression. This highlights a critical consideration: the profound impact of severe sepsis on thyroid hormone regulation and the hypothalamus-pituitary-thyroid axis.

Source: Journal of Community Hospital Internal Medicine Perspectives

DOI: 10.55729/2000-9666.1412

Authors: Nazmul Hasan, Daniel Yang, Thaer Othman, Jenny Dai-Ju

Institution: University of California, Irvine

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $500