Work

Deciphering a potential causality between autoimmune atrophic gastritis and Crohn’s disease: A report of two cases

Year: 2024

Type: article

Abstract: Autoimmune atrophic gastritis (AAG) is a chronic condition characterized by the atrophy of gastric oxyntic mucosa mediated by anti-parietal cells antibodies. AAG is a pre-neoplastic condition that is conducive to gastric neuroendocrine tumor type I and gastric adenocarcinoma. The diagnosis of AAG is made by a combined serological and histological profile. AAG-induced iron deficiency can lead to iron-deficiency anemia, whereas vitamin B12 deficiency can lead to pernicious anemia. Management of AAG is by replenishment of iron and vitamin B12 deficiencies and endoscopic surveillance. Crohn’s disease is an inflammatory bowel disease that can target any portion of the gastrointestinal tract, with a predilection for the ileo-colonic area. Crohn’s disease is characterized by skipped lesions and transmural involvement. We herein present two cases of AAG occurring in conjunction with Crohn’s disease, unveiling a potential causality between the two entities.

Source: Medical Reports

DOI: 10.1016/j.hmedic.2024.100130

Authors: Karam Karam, Houssein Chebbo, Sarah Saleh, Elias Fiani

Institution: University of Balamand

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,850