Year: 2024
Type: article
Abstract: (−)‐Vinigrol is one of the most complex and challenging molecules in total synthesis; however, the parallel biosynthetic strategy employed by nature for the synthesis of this compound has not yet been identified. In this study, we identified a minimal gene cluster encoding a diterpene cyclase (VniA) and a cytochrome P450 (VniB) which enables the synthesis of (−)‐vinigrol through three steps. VniA first cyclizes geranylgeranyl diphosphate to generate an unusual vinigrol‐type diterpene skeleton, and then VniB catalyzes the allylic C(sp 3 )−H iterative oxidation. Further genome mining investigation provides new fungal sources for this rare and valuable vinigrol‐type diterpene skeleton.
Source: Angewandte Chemie
Authors: Run Xu, Yi Zou
Institution: Southwest University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4404016265