Is an antioxidant-rich or a pro-inflammatory diet during pregnancy associated with allergic and respiratory multimorbidity in children from the ELFE birth cohort?
Year: 2024
Type: article
Study design: Observational Study
Abstract: The antioxidant capacity and the inflammatory potential of diet during pregnancy may represent a prevention opportunity for allergic and respiratory diseases. We aimed to investigate the associations between the antioxidant and the inflammatory potential of maternal diet in the last 3 months of pregnancy with allergic and respiratory diseases in children. Analyses were performed on 9679 mother–child pairs from the ELFE birth cohort. The dietary total antioxidant capacity (DTAC), without coffee, was estimated with the Trolox equivalent antioxidant capacity (TEAC), the total radical trapping antioxidant parameter (TRAP) and the ferric reducing-antioxidant power (FRAP). The inflammatory potential of the maternal diet was assessed by the energy-adjusted dietary inflammatory index (E-DII). Allergic and respiratory diseases in children up to 5·5 years were considered jointly through five allergic and respiratory multimorbidity clusters (‘asymptomatic’ - reference, ‘early wheeze without asthma’, ‘asthma only’, ‘allergies without asthma’ and ‘multi-allergic’). Multinomial logistic regressions were performed and adjusted for main confounders. A diet with a higher antioxidant potential was associated with a lower risk of belonging to the ‘early wheeze without asthma’ cluster (aOR (95 % CI) = 0·95 (0·90, 0·99) per sd of TEAC score). A higher E-DII was associated with a higher risk of belonging to the ‘asthma only’ cluster (aOR (95 % CI) = 1·09 (1·00, 1·19) per sd). No association was found with the ‘allergies without asthma’ or ‘multi-allergic’ clusters. An antioxidant-rich diet during pregnancy was associated with better respiratory health, while a pro-inflammatory diet was associated with poorer respiratory health in children up to 5·5 years, though the associations were weak.
Source: British Journal Of Nutrition
Institutions: Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, Université Paris Cité, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Université Sorbonne Paris Nord, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche Épidémiologie et Statistique, Établissement public Campus Condorcet, Etude longitudinale française depuis l'enfance, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Paris-Saclay, Médicaments et Technologies pour la Santé, Centre Hospitalier Régional et Universitaire de Nancy, Hôpital d'Enfants, Hôpital des Enfants, Développement, Adaptation et Handicap, Université de Lorraine, Université de Bordeaux, Bordeaux Population Health, Centre Hospitalier Universitaire Pointe-à-Pitre, Institut Pasteur de la Guadeloupe
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: AstraZeneca, Sanofi, Mead Johnson Nutrition, Aimmune Therapeutics, University of Cambridge, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Socialdepartementet, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Etablissement Français du Sang
OpenAlex ID: W4404020868