Year: 2023
Type: article
Abstract: Background: Food allergy (FA) is increasingly recognized as a significant global health issue, with ongoing research shedding light on its mechanisms and progression. This updated review emphasizes recent findings, particularly concerning biomarkers related to desensitization and tolerance development. Aim: The primary objective of this article is to synthesize current advancements in the understanding of FA, focusing on the role of epithelial barrier function, immune response mechanisms, and potential therapeutic strategies. Methods: This review synthesizes findings from recent studies concerning food allergy pathophysiology, specifically examining the interplay between the epithelial barrier, immune responses, and potential interventions, including emollient therapy and immunotherapy. Results: The integrity of the epithelial barrier is crucial for immune tolerance to allergens. Disruptions due to genetic mutations or environmental factors lead to increased susceptibility to FA. Current interventions, including the use of emollients and dietary modifications, have shown mixed results in preventing allergic manifestations. Additionally, new insights into immunological responses, particularly involving IgE glycosylation and T follicular helper cell dynamics, contribute to our understanding of allergy mechanisms. Conclusion: Maintaining a healthy epithelial barrier and understanding the immune system's complex interactions are vital for developing effective prevention and treatment strategies for food allergies.
Institution: National Guard Health Affairs
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404021944